What is ibogaine and how does it work?
Dr Deborah Mash, Chief Executive Officer and founder at DemeRx, is a visionary in the field of ibogaine research and has been studying the iboga plant and its medical benefits for thirty years. Through her research, she has demonstrated that purified ibogaine (the active moiety in iboga plant extracts) could have applications for treating substance use disorders, and in particular, opioid use disorder. Ibogaine is a dissociative psychedelic with oneiric properties that has multiple aforementioned anti-addictive mechanisms, as well as the ability to generate therapeutic psychological insights, suggesting promise in treating alcohol use disorders.
America’s opioid epidemic and the search for a solution
The supporting digital CBT therapy will be an additional branch of the trial which aims to help address the opioid epidemic and standardise supportive care in America.
Rao said: “Standardising support is one of the challenges in the US today. There is such different levels of therapy and resources depending on where you live – if you live in a big city there are quite a lot of resources, but if you are out in a small town in rural America, the level of resources is likely considerably less. We want to standardise that to some degree across the US, ensuring that everybody has at least a basic level of support. Buy Ibogaine Online
“Ibogaine could be a part of the solution, but when all is said and done, no drug is going to work for everybody. However, hopefully, a substantial amount of people will get a benefit from ibogaine. The need is even more pressing in light of the COVID-19 crisis, which appears to be exacerbating the opioid crisis in the US.” Buy Ibogaine Online
Ibogaine has unique and complex pharmacological properties, including a broad spectrum of binding on receptors sites as an agonist (hallucinogenic) and antagonist (antiaddictives). This reflects its peculiar clinical characteristics. The primary target sites are the NMDA, nicotinic, σ-, κ-opioid, and μ-receptors. NMDA are receptors of the messengers of glutamate, calcium, aspartate, amino acid, and glycine. Glutamate is noted to be the most important neurotransmitter booster of the CNS. The glutamate neurons are the major neuronal transmitting network of the cortex, modulating cognition, hippocampus (memory), and amygdalas (emotion). These are essential for mental functions that preserve our daily existence. Buy Ibogaine Online